There is a reason meatloaf has been a staple of dinner menus around the country for decades: it is the perfect American comfort food. With just a quick switch of gluten-free bread crumbs for oats, meatloaf can be part of your family table again. Not only is it half of a hearty meat-and-potatoes meal; it also stirs up happy memories, making it a no-brainer as to why this simple dish has graced many tables over many years.
Combine glaze ingredients in a small bowl and set aside.
In a large bowl, combine all meatloaf ingredients (except water) with your hands.
Form mixture into a ball, flattening the top, then place meatloaf into a 7-cup glass dish. Brush top of meatloaf with 1/2 of glaze mixture.
Add water to the Instant Pot®. Insert steam rack. Place glass dish on top of the steam rack. Lock lid.
Press the Meat button and cook for the default of 35 minutes. When timer beeps, release pressure naturally for 10 minutes. Quick-release any additional pressure until float valve drops and then unlock lid.
Remove meatloaf from pot and let cool at room temperature for 10 minutes. Gently tilt glass bowl over the sink and pour out any liquid. Brush on remaining glaze. Slice meatloaf and serve warm.